Beilstein J. Org. Chem.2015,11, 184–191, doi:10.3762/bjoc.11.19
barrier was found to be high as no epimerization was detected up to 150 °C, and consistent with this, density functional theory calculations give an inversion barrier of over 40 kcal/mol.
Keywords: acylphosphine; acylphosphite; chiral; DFT; NMR; nucleic acids; oligonucleotides; Introduction
Antisense